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Decommissioned, participated in exercises against the USS Enterprise-D. Its destruction was faked in a ruse to foil Ferengi attackers.

Primary setting of Star Trek: Voyager. Commanded by Captain Kathryn Janeway.

Crew discovered Iconian artifacts but is infected by a computer virus that causes antimatter containment loss. The virus causes the ship to explode with all hands lost.

Developed by Khan Noonien Singh and Starfleet Admiral Alexander Marcus to combat the Klingon Empire. The starship fights the USS Enterprise and crash lands on Starfleet Headquarters in San Francisco in Star Trek Into Darkness.

Part of the tachyon blockade during the Klingon Civil War. Later commanded by Captain Mackenzie Calhoun in Star Trek: New Frontier.

Ship on which Pavel Chekov serves as first officer. Assigned to Project Genesis and later hijacked by Khan Noonien Singh. Destroyed by Genesis Device detonation.

All crew lost killed by alien disease except Captain Ronald Tracey who was on the planet surface when the disease struck the crew.